diff --git a/Include/py_curses.h b/Include/py_curses.h
index 49fc3c9d127aa6f..3443ff7d54fc8f0 100644
--- a/Include/py_curses.h
+++ b/Include/py_curses.h
@@ -36,6 +36,13 @@
 #define NCURSES_OPAQUE 0
 #endif
 
+/* PDCurses exposes its ncurses-compatible mouse API, the one this module uses,
+   only when this is defined before the curses header is included below.
+   Ignored by other curses implementations. */
+#ifndef PDC_NCMOUSE
+#  define PDC_NCMOUSE
+#endif
+
 #if defined(HAVE_NCURSESW_NCURSES_H)
 #  include <ncursesw/ncurses.h>
 #elif defined(HAVE_NCURSESW_CURSES_H)
diff --git a/Misc/NEWS.d/next/Library/2026-06-30-21-40-00.gh-issue-152502.Kq3Vn7.rst b/Misc/NEWS.d/next/Library/2026-06-30-21-40-00.gh-issue-152502.Kq3Vn7.rst
new file mode 100644
index 000000000000000..815bc47966c40c3
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2026-06-30-21-40-00.gh-issue-152502.Kq3Vn7.rst
@@ -0,0 +1,5 @@
+Detect the :mod:`curses` mouse interface (:func:`~curses.getmouse`, the
+``BUTTON*`` constants, and others) with a configure capability probe or library
+macros instead of gating it on ncurses-specific macros.  It is now also
+available with other curses implementations that provide it, such as NetBSD
+curses and PDCurses (the latter underpins ``windows-curses``).
diff --git a/Modules/_cursesmodule.c b/Modules/_cursesmodule.c
index 52f813406268eee..51c4854aa5da52d 100644
--- a/Modules/_cursesmodule.c
+++ b/Modules/_cursesmodule.c
@@ -1502,7 +1502,7 @@ _curses_window_echochar_impl(PyCursesWindowObject *self, PyObject *ch,
                                        "echochar");
 }
 
-#ifdef NCURSES_MOUSE_VERSION
+#if defined(HAVE_CURSES_GETMOUSE) || defined(PDCURSES)
 /*[clinic input]
 _curses.window.enclose
 
@@ -3244,7 +3244,7 @@ _curses_getsyx_impl(PyObject *module)
 }
 #endif
 
-#ifdef NCURSES_MOUSE_VERSION
+#if defined(HAVE_CURSES_GETMOUSE) || defined(PDCURSES)
 /*[clinic input]
 _curses.getmouse
 
@@ -3961,7 +3961,7 @@ _curses_meta_impl(PyObject *module, int yes)
     return PyCursesCheckERR(module, meta(stdscr, yes), "meta");
 }
 
-#ifdef NCURSES_MOUSE_VERSION
+#if defined(HAVE_CURSES_GETMOUSE) || defined(PDCURSES)
 /*[clinic input]
 _curses.mouseinterval
 
@@ -5385,7 +5385,7 @@ cursesmodule_exec(PyObject *module)
     SetDictInt("COLOR_CYAN",        COLOR_CYAN);
     SetDictInt("COLOR_WHITE",       COLOR_WHITE);
 
-#ifdef NCURSES_MOUSE_VERSION
+#if defined(HAVE_CURSES_GETMOUSE) || defined(PDCURSES)
     /* Mouse-related constants */
     SetDictInt("BUTTON1_PRESSED",          BUTTON1_PRESSED);
     SetDictInt("BUTTON1_RELEASED",         BUTTON1_RELEASED);
@@ -5411,7 +5411,7 @@ cursesmodule_exec(PyObject *module)
     SetDictInt("BUTTON4_DOUBLE_CLICKED",   BUTTON4_DOUBLE_CLICKED);
     SetDictInt("BUTTON4_TRIPLE_CLICKED",   BUTTON4_TRIPLE_CLICKED);
 
-#if NCURSES_MOUSE_VERSION > 1
+#ifdef BUTTON5_PRESSED
     SetDictInt("BUTTON5_PRESSED",          BUTTON5_PRESSED);
     SetDictInt("BUTTON5_RELEASED",         BUTTON5_RELEASED);
     SetDictInt("BUTTON5_CLICKED",          BUTTON5_CLICKED);
diff --git a/Modules/clinic/_cursesmodule.c.h b/Modules/clinic/_cursesmodule.c.h
index d433e9cfc0cf278..c1916d6e0d8e1b6 100644
--- a/Modules/clinic/_cursesmodule.c.h
+++ b/Modules/clinic/_cursesmodule.c.h
@@ -683,7 +683,7 @@ _curses_window_echochar(PyObject *self, PyObject *const *args, Py_ssize_t nargs)
     return return_value;
 }
 
-#if defined(NCURSES_MOUSE_VERSION)
+#if (defined(HAVE_CURSES_GETMOUSE) || defined(PDCURSES))
 
 PyDoc_STRVAR(_curses_window_enclose__doc__,
 "enclose($self, y, x, /)\n"
@@ -726,7 +726,7 @@ _curses_window_enclose(PyObject *self, PyObject *const *args, Py_ssize_t nargs)
     return return_value;
 }
 
-#endif /* defined(NCURSES_MOUSE_VERSION) */
+#endif /* (defined(HAVE_CURSES_GETMOUSE) || defined(PDCURSES)) */
 
 PyDoc_STRVAR(_curses_window_getbkgd__doc__,
 "getbkgd($self, /)\n"
@@ -2322,7 +2322,7 @@ _curses_getsyx(PyObject *module, PyObject *Py_UNUSED(ignored))
 
 #endif /* defined(getsyx) */
 
-#if defined(NCURSES_MOUSE_VERSION)
+#if (defined(HAVE_CURSES_GETMOUSE) || defined(PDCURSES))
 
 PyDoc_STRVAR(_curses_getmouse__doc__,
 "getmouse($module, /)\n"
@@ -2345,9 +2345,9 @@ _curses_getmouse(PyObject *module, PyObject *Py_UNUSED(ignored))
     return _curses_getmouse_impl(module);
 }
 
-#endif /* defined(NCURSES_MOUSE_VERSION) */
+#endif /* (defined(HAVE_CURSES_GETMOUSE) || defined(PDCURSES)) */
 
-#if defined(NCURSES_MOUSE_VERSION)
+#if (defined(HAVE_CURSES_GETMOUSE) || defined(PDCURSES))
 
 PyDoc_STRVAR(_curses_ungetmouse__doc__,
 "ungetmouse($module, id, x, y, z, bstate, /)\n"
@@ -2419,7 +2419,7 @@ _curses_ungetmouse(PyObject *module, PyObject *const *args, Py_ssize_t nargs)
     return return_value;
 }
 
-#endif /* defined(NCURSES_MOUSE_VERSION) */
+#endif /* (defined(HAVE_CURSES_GETMOUSE) || defined(PDCURSES)) */
 
 PyDoc_STRVAR(_curses_getwin__doc__,
 "getwin($module, file, /)\n"
@@ -3116,7 +3116,7 @@ _curses_meta(PyObject *module, PyObject *arg)
     return return_value;
 }
 
-#if defined(NCURSES_MOUSE_VERSION)
+#if (defined(HAVE_CURSES_GETMOUSE) || defined(PDCURSES))
 
 PyDoc_STRVAR(_curses_mouseinterval__doc__,
 "mouseinterval($module, interval, /)\n"
@@ -3153,9 +3153,9 @@ _curses_mouseinterval(PyObject *module, PyObject *arg)
     return return_value;
 }
 
-#endif /* defined(NCURSES_MOUSE_VERSION) */
+#endif /* (defined(HAVE_CURSES_GETMOUSE) || defined(PDCURSES)) */
 
-#if defined(NCURSES_MOUSE_VERSION)
+#if (defined(HAVE_CURSES_GETMOUSE) || defined(PDCURSES))
 
 PyDoc_STRVAR(_curses_mousemask__doc__,
 "mousemask($module, newmask, /)\n"
@@ -3191,7 +3191,7 @@ _curses_mousemask(PyObject *module, PyObject *arg)
     return return_value;
 }
 
-#endif /* defined(NCURSES_MOUSE_VERSION) */
+#endif /* (defined(HAVE_CURSES_GETMOUSE) || defined(PDCURSES)) */
 
 PyDoc_STRVAR(_curses_napms__doc__,
 "napms($module, ms, /)\n"
@@ -4471,4 +4471,4 @@ _curses_has_extended_color_support(PyObject *module, PyObject *Py_UNUSED(ignored
 #ifndef _CURSES_ASSUME_DEFAULT_COLORS_METHODDEF
     #define _CURSES_ASSUME_DEFAULT_COLORS_METHODDEF
 #endif /* !defined(_CURSES_ASSUME_DEFAULT_COLORS_METHODDEF) */
-/*[clinic end generated code: output=728a704064bc8b85 input=a9049054013a1b77]*/
+/*[clinic end generated code: output=945fcc1c41f2ffe7 input=a9049054013a1b77]*/
diff --git a/configure b/configure
index dac448e91f18cc9..8c6bf8b3cfe4a9b 100755
--- a/configure
+++ b/configure
@@ -29966,6 +29966,57 @@ fi
 
 
 
+
+{ printf "%s\n" "$as_me:${as_lineno-$LINENO}: checking for ncurses-style curses function getmouse" >&5
+printf %s "checking for ncurses-style curses function getmouse... " >&6; }
+if test ${ac_cv_lib_curses_getmouse+y}
+then :
+  printf %s "(cached) " >&6
+else case e in #(
+  e) cat confdefs.h - <<_ACEOF >conftest.$ac_ext
+/* end confdefs.h.  */
+
+#define NCURSES_OPAQUE 0
+#if defined(HAVE_NCURSESW_NCURSES_H)
+#  include <ncursesw/ncurses.h>
+#elif defined(HAVE_NCURSESW_CURSES_H)
+#  include <ncursesw/curses.h>
+#elif defined(HAVE_NCURSES_NCURSES_H)
+#  include <ncurses/ncurses.h>
+#elif defined(HAVE_NCURSES_CURSES_H)
+#  include <ncurses/curses.h>
+#elif defined(HAVE_NCURSES_H)
+#  include <ncurses.h>
+#elif defined(HAVE_CURSES_H)
+#  include <curses.h>
+#endif
+
+int
+main (void)
+{
+MEVENT event; (void)getmouse(&event);
+  ;
+  return 0;
+}
+_ACEOF
+if ac_fn_c_try_compile "$LINENO"
+then :
+  ac_cv_lib_curses_getmouse=yes
+else case e in #(
+  e) ac_cv_lib_curses_getmouse=no ;;
+esac
+fi
+rm -f core conftest.err conftest.$ac_objext conftest.beam conftest.$ac_ext ;;
+esac
+fi
+{ printf "%s\n" "$as_me:${as_lineno-$LINENO}: result: $ac_cv_lib_curses_getmouse" >&5
+printf "%s\n" "$ac_cv_lib_curses_getmouse" >&6; }
+if test "x$ac_cv_lib_curses_getmouse" = xyes
+then :
+
+printf "%s\n" "#define HAVE_CURSES_GETMOUSE 1" >>confdefs.h
+
+fi
 CPPFLAGS=$ac_save_cppflags
 
 fi
diff --git a/configure.ac b/configure.ac
index d4a3bd417935f22..a65c16a05b15805 100644
--- a/configure.ac
+++ b/configure.ac
@@ -7086,6 +7086,18 @@ PY_CHECK_CURSES_FUNC([set_escdelay])
 PY_CHECK_CURSES_FUNC([set_tabsize])
 PY_CHECK_CURSES_VAR([ESCDELAY])
 PY_CHECK_CURSES_VAR([TABSIZE])
+
+dnl Probe for the X/Open getmouse(MEVENT *) signature specifically: PDCurses
+dnl declares an incompatible getmouse(void) unless built for the ncurses mouse API.
+AC_CACHE_CHECK([for ncurses-style curses function getmouse],
+  [ac_cv_lib_curses_getmouse],
+  [AC_COMPILE_IFELSE(
+    [AC_LANG_PROGRAM(_CURSES_INCLUDES, [MEVENT event; (void)getmouse(&event);])],
+    [ac_cv_lib_curses_getmouse=yes],
+    [ac_cv_lib_curses_getmouse=no])])
+AS_VAR_IF([ac_cv_lib_curses_getmouse], [yes],
+  [AC_DEFINE([HAVE_CURSES_GETMOUSE], [1],
+    [Define if you have the 'getmouse' function with the X/Open signature.])])
 CPPFLAGS=$ac_save_cppflags
 ])dnl have_curses != no
 ])dnl save env
diff --git a/pyconfig.h.in b/pyconfig.h.in
index 202b49cd22a297c..a7e18d42c2a604d 100644
--- a/pyconfig.h.in
+++ b/pyconfig.h.in
@@ -192,6 +192,9 @@
 /* Define if you have the 'filter' function. */
 #undef HAVE_CURSES_FILTER
 
+/* Define if you have the 'getmouse' function with the X/Open signature. */
+#undef HAVE_CURSES_GETMOUSE
+
 /* Define to 1 if you have the <curses.h> header file. */
 #undef HAVE_CURSES_H